Drug Delivery System

Topics: Chromatography, Thin layer chromatography, Ethanol Pages: 2 (358 words) Published: July 18, 2013
Allii Sativi Bulbus Pulveratus
Powdered Bawang Bulb

* Allii Sativi bulbus Pulveratus is Allii Sativi Bulbus that has been cut, freeze-dried or dried at a temperature not exceeding 65˚C, and reduced to a powder. Packaging and Storage – Preserve in well-closed, light-resistant containers in a cool, dry place. Labeling – Print the Official Title and the National Title of the powdered bulb on the label as directed under General Notices and Requirements Part II. Botanic characteristic (see Microscopic Examinationfor crude plant Drugs) – Powdered Bawang Bulb is pale yellow, with characteristic aromatic alliaceous odor and taste. Under a microscope, the powder shows swollen parenchyma cells with granular contents; thin epidermal cells; lignified narrow spiral and annular vessels; scattered starch grains; rhomboid crystals of calcium oxalate; sclereids of the epidermis and dry scales. Identication (Thin Layer Chromatographic Identification Test for Crude Plant Drugs) – Test solution—Transfer 1.0g of dried allii sativi Bulbus Pulveratus to a suitable glass apparatus. Extract with 10mL of a mixture of methanol and water (95:5), using any suitable method as described in Test Solution under Thin Layer Chromatographic Identification Test for Crude Plant Drugs. The filter is the Test Solution.

Application Volume—5 µL
Plate—Chromatographic silica gel.
Developing solvent system—a mixture of 1-butanol, 1-propanol,acetic acid and water. (30:10:10:10) Spray reagent—ninhydrin TS.

Procedure—Proceed as directed in thin layer Chromatographic Identification Test for Crude Plant Drugs. Develop the chromatogram in a chamber containing developing solvent system until the solvent front has moved about 15cm from the spot point. Remove the plate from the chromatographic chamber, mark the solvent front and allow to dry. Spray with the Spray reagent and heat in an oven at 105˚C for 5 to 10 minutes. Observe under daylight. Compare the chromatogram of the Test solution with the...
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